148893-10-1
Chemical Structure
HATU
- CAS No.: 148893-10-1
- Formula:C10H15F6N6OP
- Molecular Weight:380.23
IUPAC Name: 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate(V)
InChIKey: JNWBBCNCSMBKNE-UHFFFAOYSA-N
SMILES: F[P-](F)(F)(F)(F)F.C/[N+](C)=C(N(C)C)/ON1C2=NC=CC=C2N=N1
Biological Activity: HATU is a third-generation uronium salt peptide coupling reagent. HATU increases the rate of peptide coupling reactions, activates amino acids, promotes peptide bond formation in both solution-phase and solid-phase synthesis, and also facilitates peptide assembly, fragment coupling, and linear peptide cyclization. HATU can promote the N-acylation of chitosan to generate amide-linked cationic derivatives with a controllable degree of substitution. HATU is commonly used in amine acylation reactions[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HATU | 99.94% | HATU is a third-generation uronium salt peptide coupling reagent. HATU increases the rate of peptide coupling reactions, activates amino acids, promotes peptide bond formation in both solution-phase and solid-phase synthesis, and also facilitates peptide assembly, fragment coupling, and linear peptide cyclization. HATU can promote the N-acylation of chitosan to generate amide-linked cationic derivatives with a controllable degree of substitution. HATU is commonly used in amine acylation reactions. | ||||||||||||||||||||
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- [1]. Louis A. Carpino. 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive. J. Am. Chem. Soc. 1993, 115, 10, 4397-4398.
- [2]. Luca Protti, et al. HATU Coupling for Fast, Efficient, and Selective N-acylation of chitosan: DoE-optimized synthesis of cationic antibacterial derivatives. Carbohydrate Polymers Volume 380, 15 May 2026, 125012.
Keywords
