2. Others
  3. Biochemical Assay Reagents
  4. HATU

HATU is a third-generation uronium salt peptide coupling reagent. HATU increases the rate of peptide coupling reactions, activates amino acids, promotes peptide bond formation in both solution-phase and solid-phase synthesis, and also facilitates peptide assembly, fragment coupling, and linear peptide cyclization. HATU can promote the N-acylation of chitosan to generate amide-linked cationic derivatives with a controllable degree of substitution. HATU is commonly used in amine acylation reactions.

Para uso exclusivo en investigación. No vendemos a pacientes.

HATU

HATU Estructura química

No. CAS : 148893-10-1

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
25 g En stock
50 g En stock
100 g En stock
500 g En stock
> 100 g   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

HATU Related Antibodies

Top Publications Citing Use of Products

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

HATU is a third-generation uronium salt peptide coupling reagent. HATU increases the rate of peptide coupling reactions, activates amino acids, promotes peptide bond formation in both solution-phase and solid-phase synthesis, and also facilitates peptide assembly, fragment coupling, and linear peptide cyclization. HATU can promote the N-acylation of chitosan to generate amide-linked cationic derivatives with a controllable degree of substitution. HATU is commonly used in amine acylation reactions[1][2].

In Vitro

HATU (0.3-3 eq; 2 h) mediates efficient, controlled N-acylation of chitosan in DMSO, enabling targeted DS values from ~10% to ~86% for TAC and successful one-pot mixed N-acylation with aromatic carboxylic acids, with reaction efficiency optimized via Design of Experiments[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HATU Related Antibodies
Peso molecular

380.23

Fòrmula

C10H15F6N6OP
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

F[P-](F)(F)(F)(F)F.C/[N+](C)=C(N(C)C)/ON1C2=NC=CC=C2N=N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 200 mg/mL (526.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6300 mL 13.1499 mL 26.2999 mL
5 mM 0.5260 mL 2.6300 mL 5.2600 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.98%

SDS (393 KB)

COA (249 KB) HNMR (129 KB) RP-HPLC (288 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6300 mL 13.1499 mL 26.2999 mL 65.7497 mL
5 mM 0.5260 mL 2.6300 mL 5.2600 mL 13.1499 mL
10 mM 0.2630 mL 1.3150 mL 2.6300 mL 6.5750 mL
15 mM 0.1753 mL 0.8767 mL 1.7533 mL 4.3833 mL
20 mM 0.1315 mL 0.6575 mL 1.3150 mL 3.2875 mL
25 mM 0.1052 mL 0.5260 mL 1.0520 mL 2.6300 mL
30 mM 0.0877 mL 0.4383 mL 0.8767 mL 2.1917 mL
40 mM 0.0657 mL 0.3287 mL 0.6575 mL 1.6437 mL
50 mM 0.0526 mL 0.2630 mL 0.5260 mL 1.3150 mL
60 mM 0.0438 mL 0.2192 mL 0.4383 mL 1.0958 mL
80 mM 0.0329 mL 0.1644 mL 0.3287 mL 0.8219 mL
100 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6575 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

HATU Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HATU148893-10-1Biochemical Assay ReagentschitosanStaphylococcus aureusracemizationpeptide bond formationsolid-phase synthesispeptide couplinganaphylaxisamino acidschiral integrityhuman proteinsInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
HATU
Cat. No.:
HY-Y1703
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.