1. Protein Tyrosine Kinase/RTK
  2. Insulin Receptor
  3. HNMPA

HNMPA 

Cat. No.: HY-101962
Handling Instructions

HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities

For research use only. We do not sell to patients.

HNMPA Chemical Structure

HNMPA Chemical Structure

CAS No. : 132541-52-7

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Description

HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]

In Vitro

HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors[1].
HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

238.18

Formula

C11H11O4P

CAS No.
SMILES

OC(P(O)(O)=O)C1=CC=C2C=CC=CC2=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HNMPA
Cat. No.:
HY-101962
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