132541-52-7
132541-52-7
Chemical Structure
HNMPA
- CAS No.: 132541-52-7
- Formula:C11H11O4P
- Molecular Weight:238.18
IUPAC Name: (hydroxy(naphthalen-2-yl)methyl)phosphonic acid
InChIKey: AMJJLDJPDLKNJA-UHFFFAOYSA-N
SMILES: OC(P(O)(O)=O)C1=CC=C2C=CC=CC2=C1
Biological Activity: HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]
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HNMPA | HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities | |||||||||||||||||||||
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References
- [1]. K Baltensperger, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7885-9. [Content Brief]
- [2]. Peter Kovacs, et al. In vivo electrophysiological effects of insulin in the rat brain. Neuropeptides. 2009 Aug;43(4):283-93. [Content Brief]
Keywords
