1. Immunology/Inflammation
  2. STING
  3. IACS-8779

IACS-8779 

Cat. No.: HY-130116
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IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy.

For research use only. We do not sell to patients.

IACS-8779 Chemical Structure

IACS-8779 Chemical Structure

CAS No. : 2243079-26-5

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Description

IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy[1].

In Vivo

Mice are implanted bilaterally with B16-Ova, and IACS-8779 (compound 1a) is administered at 10 μg dose with three intra-tumoral injections, on one flank only, on day 6, 9, 12 post implantation. While IACS-8779 shows comparable antitumor activity on the injected flank, IACS-8779 achieves superior regression on the untreated tumor in the contralateral flank, suggesting a more significant systemic immune response compared to the benchmark analogs. Treatment with IACS-8779 also results in a higher number of mice cured of both tumors compared to benchmarks[1].

Molecular Weight

689.56

Formula

C₂₁H₂₅N₉O₁₀P₂S₂

CAS No.

2243079-26-5

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Keywords:

IACS-8779IACS8779IACS 8779STINGStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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IACS-8779
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