Indalpine  (Synonyms: LM 5008)

Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing ³H-5-HT bound to brain membranes with the IC₅₀ of 36 μM^[1]. Indalpine, two antidepressant agent^[2].

In keeping with its potent reuptake-blocking property, acute IV Indalpine produces a marked decrease in the firing rate of dorsal raphe 5-HT neurons (ED50 0.33 mg/kg). The firing rate of dorsal raphe 5-HT neurons is assessed following 2-, 7- and 14-day treatments with Indalpine (5 mg/day IP). After 2 days, the firing rate of 5-HT neurons is greatly reduced, after 7 days it has recovered partially and after 14 days it has returned to normal^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

228.33

C₁₅H₂₀N₂

63758-79-2

C1(CCC2CCNCC2)=CNC3=C1C=CC=C3

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• [1]. R Samanin, et al. Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology (Berl). 1980;68(1):99-104.  [Content Brief]

  [2]. P Blier, et al. Effects of the two antidepressant drugs mianserin and Indalpine on the serotonergic system: single-cell studies in the rat. Psychopharmacology (Berl). 1984;84(2):242-9.  [Content Brief]