Isopropyl unoprostone  (Synonyms: Unoprostone isopropyl ester; UF-021)

Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca²⁺-activated K⁺ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity^[1][2].

BK channels^[1]

Isopropyl unoprostone (0.01-1 μM; 24 h) protects against H₂O₂-induced 661W cell death^[2].
Isopropyl unoprostone (0.1-3 μM; 24 h) reduced the morphological change of 661W cells and protects against light-induced cell death^[2].
Isopropyl unoprostone (0.001-1 μM; 48 h) suppresses light-induced phagocytotic dysfunction in ARPE-19 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

424.61

C₂₅H₄₄O₅

120373-24-2

Liquid

Colorless to light yellow

O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](CCC(CCCCCCC)=O)[C@H](O)C[C@@H]1O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Haria M, et al. Unoprostone (isopropyl unoprostone). Drugs Aging. 1996 Sep;9(3):213-8; discussion 219-20.   [Content Brief]

  [2]. Tsuruma K, et al. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels. Mol Vis. 2011;17:3556-65.  [Content Brief]