2. Others Cell Cycle/DNA Damage
  3. Biochemical Assay Reagents Eukaryotic Initiation Factor (eIF)
  4. ISRIB

ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research.

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CAS 番号 : 548470-11-7

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
5 mg $60 在庫あり
10 mg $95 在庫あり
25 mg $190 在庫あり
50 mg $320 在庫あり
100 mg $520 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 26 publication(s) in Google Scholar

Other Forms of ISRIB:

ISRIB 関連抗体

Top Publications Citing Use of Products

    ISRIB purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Dec:88:103905.  [Abstract]

    Schematic illustrating ISRIB treatment regimen (20 mg/kg, administered twice weekly from weeks 4–8) in CCl4-induced fibrotic mouse models. (B) Representative images of HE staining in liver sections after CCl4 treatment.

    ISRIB purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Dec:88:103905.  [Abstract]

    Schematic illustrating ISRIB treatment regimen (20 mg/kg, administered twice weekly from weeks 4–8) in CCl4-induced fibrotic mouse models. Relative gene expression levels of ATF4 in liver tissues after CCl4 injection for 8 weeks (n = 4).

    ISRIB purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2024 May 8;16(1):35.  [Abstract]

    Protein expression levels of ATF4, DDIT4, NIBAN1, p62, ATG5, and LC3-I/II were analyzed by Western blot in CAL 27 cells at 4 h after treatment with 1 mmol/L phenformin (Phen), 200 nmol/L ISRIB, or DMSO as a control.

    ISRIB purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2024 May 8;16(1):35.  [Abstract]

    CAL 27 cells were treated with 1 mmol/L phenformin (Phen) or with 200 nmol/L ISRIB or 1 μmol/L GSK2606414 or DMSO as a control. At 24 h, cells were collected and analyzed by the CCK-8 assay for cell viability.

    ISRIB purchased from MedChemExpress. Usage Cited in: J Virol. 2018 Jul 31;92(16). pii: e00600-18.  [Abstract]

    MARC-145 cells grown in six-well plates are treated with 0.5 mM Ars at 37°C for 1 h. The medium is changed to medium containing different concentrations of ISRIB and after 25 min, the cells are treated with puromycin, incubated at 37°C for 25 min, and lysed for western blotting analysis.

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research[1][2][3].

    体外実験

    ISRIB (200 nM, 2 h) blocks stress granule formation induced by eIF2α phosphorylation in U2OS cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ISRIB 関連抗体
    体内実験

    ISRIB (0.25 mg/kg, i.p., daily) restores translation in prion-diseased mice at downstream of eIF2α phosphorylation, confering neuroprotection in prion-diseased mice [2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    451.34

    分子式

    C22H24Cl2N2O4
    CAS 番号
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C(NC1CCC(NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 5.83 mg/mL (12.92 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2156 mL 11.0781 mL 22.1562 mL
    5 mM 0.4431 mL 2.2156 mL 4.4312 mL
    10 mM 0.2216 mL 1.1078 mL 2.2156 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

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    体積 （終了）

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    体内:

    The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

    • Protocol 1

      45% saline, 50% PEG 400, 5% DMSO

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    純度とドキュメンテーション

    純度: 99.0%

    COA (243 KB) HNMR (270 KB) RP-HPLC (251 KB) MS (228 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2156 mL 11.0781 mL 22.1562 mL 55.3906 mL
    5 mM 0.4431 mL 2.2156 mL 4.4312 mL 11.0781 mL
    10 mM 0.2216 mL 1.1078 mL 2.2156 mL 5.5391 mL
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    ISRIB Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ISRIB548470-11-7Biochemical Assay ReagentsEukaryotic Initiation Factor (eIF)neurological disordersISRinhibitoreIF2BInhibitorinhibit

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    製品名:
    ISRIB
    製品番号:
    HY-12495A
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