2. Neuronal Signaling
  3. Dopamine Transporter Monoamine Oxidase
  4. J147

J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB). J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD).

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J147

J147 構造式

CAS 番号 : 1807913-16-1

容量 価格（税別） 在庫状況 数量
1 mg $71 在庫あり
5 mg $179 お問い合わせ
10 mg   お問い合わせ  
50 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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J147 関連抗体

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Monoamine Oxidase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
MAO-A MAO-B

  • 生物活性

  • 純度とドキュメンテーション

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製品説明

J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J147 can pass the blood brain barrier (BBB). J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter. J147 plays an impotant role in Alzheimer’s disease (AD)[1].

Cellular Effect
Cell Line Type Value Description References
Cerebral cortex neuron EC50
0.033 μM
Compound: J147
Neuroprotective activity in rat primary cortical neurons assessed as reduction in trophic factor withdrawal after 2 days by fluorescent live-dead assay
Neuroprotective activity in rat primary cortical neurons assessed as reduction in trophic factor withdrawal after 2 days by fluorescent live-dead assay
[PMID: 23582448]
Cortical neurone EC50
25 nM
Compound: J147
Neuroprotective activity against rat Primary cortical neuron cells assessed as rescue of cell death incubated for 2 days by fluorescent live-dead assay
Neuroprotective activity against rat Primary cortical neuron cells assessed as rescue of cell death incubated for 2 days by fluorescent live-dead assay
[PMID: 32942072]
HT-22 EC50
0.02 μM
Compound: J147
Neuroprotective activity in mouse HT22 cells assessed as reduction in glutamate-induced oxidative stress incubated for 30 mins prior to glutamate-challenge measured after 24 hrs by MTT assay
Neuroprotective activity in mouse HT22 cells assessed as reduction in glutamate-induced oxidative stress incubated for 30 mins prior to glutamate-challenge measured after 24 hrs by MTT assay
[PMID: 23582448]
Hippocampal neurone EC50
200 nM
Compound: J147
Neuroprotective activity against amyloid beta induced cell death in rat Primary hippocampal neuron cells assessed as increase in cell viability incubated for 2 days by lactate dehydrogenase release assay
Neuroprotective activity against amyloid beta induced cell death in rat Primary hippocampal neuron cells assessed as increase in cell viability incubated for 2 days by lactate dehydrogenase release assay
[PMID: 32942072]
臨床実験
分子量

350.33

分子式

C18H17F3N2O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 40 mg/mL (114.18 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8545 mL 14.2723 mL 28.5445 mL
5 mM 0.5709 mL 2.8545 mL 5.7089 mL
10 mM 0.2854 mL 1.4272 mL 2.8545 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.90%

COA (248 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8545 mL 14.2723 mL 28.5445 mL 71.3613 mL
5 mM 0.5709 mL 2.8545 mL 5.7089 mL 14.2723 mL
10 mM 0.2854 mL 1.4272 mL 2.8545 mL 7.1361 mL
15 mM 0.1903 mL 0.9515 mL 1.9030 mL 4.7574 mL
20 mM 0.1427 mL 0.7136 mL 1.4272 mL 3.5681 mL
25 mM 0.1142 mL 0.5709 mL 1.1418 mL 2.8545 mL
30 mM 0.0951 mL 0.4757 mL 0.9515 mL 2.3787 mL
40 mM 0.0714 mL 0.3568 mL 0.7136 mL 1.7840 mL
50 mM 0.0571 mL 0.2854 mL 0.5709 mL 1.4272 mL
60 mM 0.0476 mL 0.2379 mL 0.4757 mL 1.1894 mL
80 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.8920 mL
100 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.7136 mL
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J147 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

J1471807913-16-1J 147J-147Dopamine TransporterMonoamine OxidaseDATSLC6A3MAOBBBmonoamineoxidaseMAO BdopamineAlzheimer? diseaseneuroprotectiveInhibitorinhibitorinhibit

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製品名:
J147
製品番号:
HY-13779A
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