2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. JNJ-6204

JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

JNJ-6204

JNJ-6204 構造式

CAS 番号 : 2765264-50-2

容量 価格（税別） 在庫状況 数量
1 mg $490 在庫あり
5 mg   お問い合わせ  
10 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

JNJ-6204 関連抗体

Top Publications Citing Use of Products

Casein Kinase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CK1 CK2

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target

IC50: 2.3 nM (CSNK1D)[2]
体外実験

JNJ-6204 inhibits CSNK1D in the BRET whole cell binding assay and in the PER2 translocation whole cell functional assay with IC50s of 72 nM and 542 nM, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-6204 関連抗体
分子量

370.41

分子式

C19H11D6FN6O
CAS 番号
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(N=C1)C2=NN3C(COC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C3)=C2C4=C5C(NN=C5)=NC=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (134.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6997 mL 13.4986 mL 26.9971 mL
5 mM 0.5399 mL 2.6997 mL 5.3994 mL
10 mM 0.2700 mL 1.3499 mL 2.6997 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.75%

COA (256 KB) HNMR (162 KB) RP-HPLC (119 KB) LCMS (153 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6997 mL 13.4986 mL 26.9971 mL 67.4928 mL
5 mM 0.5399 mL 2.6997 mL 5.3994 mL 13.4986 mL
10 mM 0.2700 mL 1.3499 mL 2.6997 mL 6.7493 mL
15 mM 0.1800 mL 0.8999 mL 1.7998 mL 4.4995 mL
20 mM 0.1350 mL 0.6749 mL 1.3499 mL 3.3746 mL
25 mM 0.1080 mL 0.5399 mL 1.0799 mL 2.6997 mL
30 mM 0.0900 mL 0.4500 mL 0.8999 mL 2.2498 mL
40 mM 0.0675 mL 0.3375 mL 0.6749 mL 1.6873 mL
50 mM 0.0540 mL 0.2700 mL 0.5399 mL 1.3499 mL
60 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1249 mL
80 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.8437 mL
100 mM 0.0270 mL 0.1350 mL 0.2700 mL 0.6749 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

JNJ-6204 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-62042765264-50-2JNJ6204JNJ 6204Casein Kinasegood brain exposureInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
JNJ-6204
製品番号:
HY-148233S
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.