JNJ-6204

Cat. No.: HY-148233S Pureté: 99.60%: Fiche technique
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JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC₅₀=2.3 nM; CSNK1E IC₅₀=137 nM). JNJ-6204 shows good brain exposure.

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JNJ-6204 Chemical Structure

CAS No. : 2765264-50-2

Size	Stock	Quantité
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	Obtenir un devis
10 mg	Obtenir un devis

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Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Casein Kinase:

Voir toutes les isoformes

CK1 CK2

Activité biologique
Pureté et documentation
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Description

JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC₅₀=2.3 nM; CSNK1E IC₅₀=137 nM). JNJ-6204 shows good brain exposure^[1]^[2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC₅₀ & Target

IC₅₀: 2.3 nM (CSNK1D)^[2]

In Vitro

JNJ-6204 inhibits CSNK1D in the BRET whole cell binding assay and in the PER2 translocation whole cell functional assay with IC₅₀s of 72 nM and 542 nM, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

370.41

Formule

C₁₉H₁₁D₆FN₆O

CAS No.

2765264-50-2

Unlabeled CAS

2765264-58-0

Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(N=C1)C2=NN3C(COC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C3)=C2C4=C5C(NN=C5)=NC=C4

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (134.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6997 mL	13.4986 mL	26.9971 mL
5 mM	0.5399 mL	2.6997 mL	5.3994 mL
10 mM	0.2700 mL	1.3499 mL	2.6997 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

Pureté et documentation

Purity: 99.75%

Select Batch:

Fiche technique (277 KB) SDS (252 KB)

COA (256 KB) HNMR (162 KB) RP-HPLC (119 KB) LCMS (153 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Terry Patrick LEBOLD, et al. Casein kinase 1 delta modulators. WO2022058920A1.

[2]. https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-6204

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6997 mL	13.4986 mL	26.9971 mL	67.4928 mL
	5 mM	0.5399 mL	2.6997 mL	5.3994 mL	13.4986 mL
	10 mM	0.2700 mL	1.3499 mL	2.6997 mL	6.7493 mL
	15 mM	0.1800 mL	0.8999 mL	1.7998 mL	4.4995 mL
	20 mM	0.1350 mL	0.6749 mL	1.3499 mL	3.3746 mL
	25 mM	0.1080 mL	0.5399 mL	1.0799 mL	2.6997 mL
	30 mM	0.0900 mL	0.4500 mL	0.8999 mL	2.2498 mL
	40 mM	0.0675 mL	0.3375 mL	0.6749 mL	1.6873 mL
	50 mM	0.0540 mL	0.2700 mL	0.5399 mL	1.3499 mL
	60 mM	0.0450 mL	0.2250 mL	0.4500 mL	1.1249 mL
	80 mM	0.0337 mL	0.1687 mL	0.3375 mL	0.8437 mL
	100 mM	0.0270 mL	0.1350 mL	0.2700 mL	0.6749 mL

JNJ-6204 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-62042765264-50-2JNJ6204JNJ 6204Casein Kinasegood brain exposureInhibitorinhibitorinhibit

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JNJ-6204

JNJ-6204 Related Antibodies

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Casein Kinase:

Activité biologique

Pureté et documentation

Références

Avis client

JNJ-6204 Related Antibodies

Calculateur de molarité

Calculateur de dilution