2. Metabolic Enzyme/Protease
  3. Ketohexokinase
  4. KHK-IN-4

KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research.

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KHK-IN-4

KHK-IN-4 화학구조

CAS No. : 3034829-40-5

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100 mg   견적 받기  
250 mg   견적 받기  

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KHK-IN-4 Related Antibodies

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KHK-A KHK-C

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제품 설명

KHK-IN-4 (compound 14) is a potent ketohexokinase (KHK) inhibitor. KHK-IN-4 can be used for fructose metabolic disease research[1].

Cellular Effect
Cell Line Type Value Description References
Hepatocyte IC50
>150 μM
Compound: ent-14
Toxicity in human Primary hepatocyte incubated for 48 hrs by Celltiter-Glo assay
Toxicity in human Primary hepatocyte incubated for 48 hrs by Celltiter-Glo assay
[PMID: 37766386]
HepG2 IC50
>150 μM
Compound: ent-14
Cytotoxicity against human HepG2 cells measured after 48 hrs by microscopy based analysis
Cytotoxicity against human HepG2 cells measured after 48 hrs by microscopy based analysis
[PMID: 37766386]
HepG2 IC50
>150 μM
Compound: ent-14
Mitotoxicity in human HepG2 cells incubated for 2 hrs by Celltiter-Glo assay
Mitotoxicity in human HepG2 cells incubated for 2 hrs by Celltiter-Glo assay
[PMID: 37766386]
HepG2 IC50
196 nM
Compound: ent-14
Antiproliferative activity against human HepG2 cells incubated for 3 hrs by LC-MS analysis
Antiproliferative activity against human HepG2 cells incubated for 3 hrs by LC-MS analysis
[PMID: 37766386]
분자량

366.41

화학식

C18H24F2N4O2
CAS No.
SMILES

C[C@H]1CCN1C2=NC(N3CC[C@@H](C3)CCC(O)=O)=C4C(C(F)(CC4)F)=N2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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KHK-IN-4 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KHK-IN-43034829-40-5KetohexokinaseKHKfructose metabolic diseaseketohexokinaseInhibitorinhibitorinhibit

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상품명:
KHK-IN-4
Cat. No.:
HY-149605
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