Kisspeptin 234 TFA 

Kisspeptin 234 TFA, is a 10 amino acid peptide as well as a kisspeptin receptor (KISS1, GPR54) antagonist. Kisspeptin 234 TFA is an analog of Kisspeptin 10^[1].

Kisspeptin 234 (1 mg/kg, ip, daily, 28 days) TFA can inhibit the anti-fibrotic effect of Kisspeptin-13 in the bleomycin (BLM)-induced lung fibrosis model of C57BL/6 mice, especially in weight loss, decreased survival rate, increased lung coefficient, and massive infiltration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1409.43

C₆₅H₇₉F₃N₁₈O₁₅

1848962-29-7

Solid

White to off-white

Ac-Ala-Asn-Trp-Asn-Gly-Phe-Gly-Trp-Arg-Phe-NH2

Ac-ANWNGFGWRF-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Lei Z, et al. Kisspeptin‑13 inhibits bleomycin‑induced pulmonary fibrosis through GPR54 in mice. Mol Med Rep. 2019 Aug;20(2):1049-1056.  [Content Brief]