2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. L-706000 free base

L-706000 (MK 499) free base is a potent hERG channel blocker with an IC50 of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias.

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L-706000 free base

L-706000 free base Estructura química

No. CAS : 161799-18-4

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25 mg Obtener un presupuesto 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks
50 mg Obtener un presupuesto 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks
100 mg   Obtener un presupuesto  
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Descripciòn

L-706000 (MK 499) free base is a potent hERG channel blocker with an IC50 of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias[1].

IC50 & Target

IC50: 32 nM (hERG channel)[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
0.67 μM
Compound: MK-499
Displacement of [35S]MK499 from human ERG expressed in HEK293 cells
Displacement of [35S]MK499 from human ERG expressed in HEK293 cells
[PMID: 20423086]
Peso molecular

467.58

Fòrmula

C25H29N3O4S
No. CAS
SMILES

O[C@@H]1CC2(CCN([C@@](CCC3=C4)([H])CC3=CC=C4C#N)CC2)OC(C1=C5)=CC=C5N[S](C)(=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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L-706000 free base Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-706000161799-18-4MK 499L706000L 706000MK499MK-499Potassium ChannelKcsAhERG channel blockerantiarrhythmic agentmalignant ventricular tachyarrhythmiasInhibitorinhibitorinhibit

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Nombre del producto:
L-706000 free base
Cat. No.:
HY-106912A
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