161799-18-4
Chemical Structure
L-706000 free base
Synonym(s): MK 499 free base
- CAS No.: 161799-18-4
- Formula:C25H29N3O4S
- Molecular Weight:467.58
IUPAC Name: N-((R)-1'-((R)-6-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)-4-hydroxyspiro[chromane-2,4'-piperidin]-6-yl)methanesulfonamide
InChIKey: NIYGLRKUBPNXQS-FYYLOGMGSA-N
SMILES: O[C@@H]1CC2(CCN([C@@](CCC3=C4)([H])CC3=CC=C4C#N)CC2)OC(C1=C5)=CC=C5N[S](C)(=O)=O
Biological Activity: L-706000 (MK 499) free base is a potent hERG channel blocker with an IC50 of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias[1].
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L-706000 free base | L-706000 (MK 499) free base is a potent hERG channel blocker with an IC50 of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias. | |||||||||||||||||||||
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