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  4. L-Ornithine L-aspartate

L-Ornithine L-aspartate  (Synonyms: L-Ornithine L-aspartate)

製品番号: HY-A0282 純度: 98.0%
COA 取扱説明書 Technical Support

L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids with oral activity: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. L-Ornithine L-aspartate also improves mitochondrial functions.

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L-Ornithine L-aspartate

L-Ornithine L-aspartate 構造式

CAS 番号 : 3230-94-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in Water USD 27 在庫あり
Solid
100 mg $25 在庫あり
500 mg $50 在庫あり
1 g $70 在庫あり
5 g $140 在庫あり
10 g $196 在庫あり
50 g   お問い合わせ  

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L-Ornithine L-aspartate 関連抗体

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製品説明

L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids with oral activity: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. L-Ornithine L-aspartate also improves mitochondrial functions[1][2][3][4].

体外実験

L-Ornithine L-aspartate (5 mM, 24 h) increases the redox activity of mitochondria in SH-SY5Y cells, and counteracts ROT- and 6-OHDA- induced mitochondrial depolarization[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Ornithine L-aspartate 関連抗体
体内実験

L-Ornithine L-aspartate (300 mg/kg/h, i.v. infusions) prevents ammonia-precipitated coma in portal-systemic encephalopathy (PSE) rats[2].
L-Ornithine L-aspartate (2 g/kg, p.o. for 10 days) protects Thioacetamide (HY-Y0698)-induced hepatic damage in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Thioacetamide (250 mg/kg, i.p. for 2 days) induced hepatopathy in rats[3]
Dosage: 2 g/kg
Administration: p.o. for 10 days
Result: Restored hepatic architecture and lobular structure in rat liver sections (histological evaluation).
Reduced levels of AST, ALT, ALKP, BRN, and tissue TBARS concentration.
臨床実験
分子量

265.26

分子式

C9H19N3O6
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CC(O)=O)C(O)=O.N[C@@H](CCCN)C(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 175 mg/mL (659.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7699 mL 18.8494 mL 37.6989 mL
5 mM 0.7540 mL 3.7699 mL 7.5398 mL
10 mM 0.3770 mL 1.8849 mL 3.7699 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (188.49 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 98.0%

COA (253 KB) HNMR (271 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.7699 mL 18.8494 mL 37.6989 mL 94.2472 mL
5 mM 0.7540 mL 3.7699 mL 7.5398 mL 18.8494 mL
10 mM 0.3770 mL 1.8849 mL 3.7699 mL 9.4247 mL
15 mM 0.2513 mL 1.2566 mL 2.5133 mL 6.2831 mL
20 mM 0.1885 mL 0.9425 mL 1.8849 mL 4.7124 mL
25 mM 0.1508 mL 0.7540 mL 1.5080 mL 3.7699 mL
30 mM 0.1257 mL 0.6283 mL 1.2566 mL 3.1416 mL
40 mM 0.0942 mL 0.4712 mL 0.9425 mL 2.3562 mL
50 mM 0.0754 mL 0.3770 mL 0.7540 mL 1.8849 mL
60 mM 0.0628 mL 0.3142 mL 0.6283 mL 1.5708 mL
80 mM 0.0471 mL 0.2356 mL 0.4712 mL 1.1781 mL
100 mM 0.0377 mL 0.1885 mL 0.3770 mL 0.9425 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Ornithine L-aspartate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ornithine3230-94-2Amino Acid DerivativesliverfailurecirrhosisPSEInhibitorinhibitorinhibit

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