2. Others Protein Tyrosine Kinase/RTK Apoptosis
  3. Reference Standards Anaplastic lymphoma kinase (ALK) ROS Kinase Apoptosis
  4. Lorlatinib (Standard)

Lorlatinib (Standard)  (Synonyms: PF-06463922 (Standard))

Cat. No.: HY-12215R Pureté: 99.92%
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Lorlatinib (Standard) is the analytical standard of Lorlatinib. This product is intended for research and analytical applications. Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM (ALKL1196), 14-80 nM (ALKG1269A), 38-50 nM (ALK1151Tins), 77-113 nM (ALKG1202R), respectively.

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Lorlatinib (Standard)

Lorlatinib (Standard) Chemical Structure

CAS No. : 1454846-35-5

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Information
Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Masse moléculaire

406.41

Formule

C21H19FN6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1C(C#N)=C2C(CN(C)C(C3=C([C@@H](C)OC4=C(N)N=CC2=C4)C=C(F)C=C3)=O)=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Lorlatinib (Standard) Related Classifications

  • Calculateur de molarité

  • Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lorlatinib (Standard)1454846-35-5PF-06463922 (Standard)Reference StandardsAnaplastic lymphoma kinase (ALK)ROS KinaseApoptosisAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246NSCLCNeuroblastomaCarcinomabrain-penetrantmutationthird-generationtyrosinekinaseInhibitorinhibitorinhibit

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