2. Neuronal Signaling
  3. Monoamine Oxidase
  4. PXS-5505

PXS-5505  (Synonyms: LOX-IN-3 dihydrochloride monohydrate)

Cat. No.: HY-138625B
Instrucciones de manejo Technical Support

PXS-5505 (LOX-IN-3 dihydrochloride monohydrate) (Compound 33) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 can be used for fibrosis, cancer and angiogenesis research.

Para uso exclusivo en investigación. No vendemos a pacientes.

PXS-5505

PXS-5505 Estructura química

No. CAS : 2414974-55-1

Tamaño Stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  
250 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of PXS-5505:

Other Forms of PXS-5505:

PXS-5505 Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE PXS-5505

Ver todos los productos específicos de isoformas Monoamine Oxidase:

Ver todas las isoformas
MAO-A MAO-B

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

PXS-5505 (LOX-IN-3 dihydrochloride monohydrate) (Compound 33) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 can be used for fibrosis, cancer and angiogenesis research[1].

IC50 & Target

IC50: <1 μM (human LOXL2), <10 μM (bovine LOX)[1]
In Vitro

PXS-5505 (Compound 33) inhibits the bovine LOX and human LOXL2 activities with IC50 values of <10 μM and <1 μM, respectively[1].
PXS-5505 exhibits sustained inhibition of LOXL1 and LOXL2[1].
PXS-5505 is less active against SSAO/VAP-1 and MAO-B activities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PXS-5505 Related Antibodies
In Vivo

PXS-5505 (LOX-IN-3 dihydrochloride monohydrate) (Compound 33) (30 mg/kg; orally; once) inhibits lysyl oxidase activity in rats[1].
PXS-5505 (LOX-IN-3 dihydrochloride monohydrate) (10 mg/kg; orally; daily for 14 days) reduces kidney fibrosis in unilateral ureteric obstruction (UUO) mice model[1].
PXS-5505 (LOX-IN-3 dihydrochloride monohydrate) (15 mg/kg; orally; daily for 21 days) reduces lung fibrosis in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 30 mg/kg
Administration: Oral administration, single dose
Result: Completely abolished lysyl oxidase activity. Plasma concentrations of tested compound are far below the IC50 after 8 hours, the half-life of recovery is between 2-3 days (ear) and 24 hours (aorta).
Animal Model: Unilateral ureteric obstruction (UUO) model of acute kidney fibrosis in mice[1]
Dosage: 10 mg/kg
Administration: Oral gavage, daily for 14 days
Result: Increased kidney weight and thickness and reduced the area of fibrosis.
Animal Model: C57Bl/6 mice, Bleomycin-induced lung fibrosis model
Dosage: 15 mg/kg
Administration: Oral gavage, daily for 21 days
Result: Significantly reduced the Ashcroft score and the lung weight.
Ensayo clínico
Peso molecular

371.26

Fòrmula

C13H17Cl2FN2O3S
No. CAS
SMILES

NC/C=C(F)/CS(=O)(C1=CC=CC2=C1N=CC=C2)=O.Cl.O.Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PXS-5505 Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PXS-55052414974-55-1LOX-IN-3 dihydrochloridePXS5505PXS 5505Monoamine OxidaseMAOfibrosislysyl oxidaseLOXL2Inhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
PXS-5505
Cat. No.:
HY-138625B
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.