1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Margatoxin

Margatoxin 

Cat. No.: HY-P1280
Handling Instructions

Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Margatoxin Chemical Structure

Margatoxin Chemical Structure

CAS No. : 145808-47-5

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Description

Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2].

IC50 & Target

Kd: 11.7 pM (Kv1.3), 6.4 pM (Kv1.2) and 4.2 nM (Kv1.1)[1]

In Vivo

Margatoxin (i.p.; 1 pmol/g) significantly decreases thiogycollate-induced leukocyte transmigration in the peritoneal cavity in 12-week-old C57BL6/J mice[2].

Molecular Weight

4178.95

Formula

C₁₇₈H₂₈₆N₅₂O₅₀S₇

CAS No.

145808-47-5

Sequence

ThrIleIleAsnValLysCysThrSerProLysGlnCysLeuProProCysLysAlaGlnPheGlyGlnSerAlaGlyAlaLysCysMetAsnGlyLysCysLysCysTyrProHis(Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36)

Sequence Shortening

TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH(Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MargatoxinPotassium ChannelKcsAalpha-KTxscorpiontoxinKv1.3Kv1.2Kv1.139amino-acid-longpeptideCentruroidesmargaritatuschannelInhibitorinhibitorinhibit

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Margatoxin
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HY-P1280
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