2. Academic Validation
  3. Preparation of 5-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyloxy)-6-hydroxynap htho[2,3- f]quinoline-7,12-dione (FT-Alz), a new-type, potentially antitumor substance with various biological activities

Preparation of 5-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyloxy)-6-hydroxynap htho[2,3- f]quinoline-7,12-dione (FT-Alz), a new-type, potentially antitumor substance with various biological activities

  • Bioorg Med Chem Lett. 2000 Feb 7;10(3):203-7. doi: 10.1016/s0960-894x(99)00655-1.
T Tsuchiya 1,  Y Takagi,  H Yamada
Affiliations

Affiliation

  • 1 Institute of Bioorganic Chemistry, Kawasaki, Japan.
PMID: 10698436 DOI: 10.1016/s0960-894x(99)00655-1
Abstract

The title compound (6), its structure being imaginatively created, has been prepared through coupling of alizarine blue (2), a classical dye, and 3,4-di-O-acetyl-2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl bromide (3). Compound 6 has considerably higher and different antitumor activity from that of doxorubicin or its analogue (10), and, further, has properties to reverse multidrug resistance (by P-glycoprotein), to inhibit Topoisomerase II, and to induce Apoptosis.

Figures