2. Academic Validation
  3. ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma

ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma

  • Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3254-7. doi: 10.1073/pnas.051484398.
G H Su 1,  R Bansal,  K M Murphy,  E Montgomery,  C J Yeo,  R H Hruban,  S E Kern
Affiliations

Affiliation

  • 1 Department of Oncology, Pathology, and Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
PMID: 11248065 DOI: 10.1073/pnas.051484398
Abstract

DPC4 is known to mediate signals initiated by type beta transforming growth factor (TGFbeta) as well as by other TGFbeta superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFbeta receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic Cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.

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