2. Academic Validation
  3. Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3

Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3

  • Org Lett. 2001 Jan 25;3(2):247-50. doi: 10.1021/ol006891x.
S B Singh 1,  D L Zink,  A W Dombrowski,  G Dezeny,  G F Bills,  J P Felix,  R S Slaughter,  M A Goetz
Affiliations

Affiliation

  • 1 Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065-0900, USA. [email protected]
PMID: 11430046 DOI: 10.1021/ol006891x
Abstract

[figure: see text] Blockers of the voltage-gated Potassium Channel Kv1.3 are potential immunosuppressants. Candelalides A-C are three novel diterpenoid pyrones that block this channel. The structure, stereochemistry, and activity against Kv1.3 are described.

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