2. Academic Validation
  3. Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

  • Bioorg Med Chem Lett. 2001 Oct 8;11(19):2655-7. doi: 10.1016/s0960-894x(01)00528-5.
K Chibale 1,  H Haupt,  H Kendrick,  V Yardley,  A Saravanamuthu,  A H Fairlamb,  S L Croft
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa. [email protected]
PMID: 11551771 DOI: 10.1016/s0960-894x(01)00528-5
Abstract

Sulfonamide and urea derivatives of quinacrine with varying methylene spacer lengths were synthesised and tested for inhibition of trypanothione reductase (TryR) and for activity in vitro against strains of the parasitic protozoa Trypanosoma, Leishmania, and Plasmodium. These derivatives are superior inhibitors of TryR relative to quinacrine with the best compound being 40 times more potent. Urea derivatives generally displayed good in vitro activity against all parasites.

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