2. Academic Validation
  3. Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile

Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile

  • Phytomedicine. 1999 Nov;6(5):341-5. doi: 10.1016/S0944-7113(99)80056-7.
G A Wächter 1,  S Valcic,  M L Flagg,  S G Franzblau,  G Montenegro,  E Suarez,  B N Timmermann
Affiliations

Affiliation

  • 1 Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson 85721, USA.
PMID: 11962541 DOI: 10.1016/S0944-7113(99)80056-7
Abstract

Screening of Plants from South America for antitubercular activity and subsequent assay-guided fractionation resulted in the isolation and characterization of several pentacyclic triterpenoids. The MIC values of 22 triterpenoids were determined using the radiorespiratory BACTEC assay and range from 8 microM to above 128 microM. The structure-activity relationships are discussed.

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