2. Academic Validation
  3. Discovery of potent and selective small molecule NPY Y5 receptor antagonists

Discovery of potent and selective small molecule NPY Y5 receptor antagonists

  • Bioorg Med Chem Lett. 2002 Jul 8;12(13):1767-9. doi: 10.1016/s0960-894x(02)00287-1.
Imadul Islam 1,  Dale Dhanoa,  John Finn,  Ping Du,  Mary W Walker,  John A Salon,  Jack Zhang,  Charles Gluchowski
Affiliations

Affiliation

  • 1 Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, NJ 07652. USA.
PMID: 12067557 DOI: 10.1016/s0960-894x(02)00287-1
Abstract

The discovery of a new class of sulfonamide NPY Y5 receptor antagonists is described. Optimization of this series led to the identification of compounds with high affinity for the hY5 subtype and excellent selectivity over the other NPY receptor subtypes. The SAR for this series was examined and a model for understanding the ligand-receptor interactions was developed.

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