2. Academic Validation
  3. Human neutrophil azurocidin synergizes with leukocyte elastase and cathepsin G in the killing of Capnocytophaga sputigena

Human neutrophil azurocidin synergizes with leukocyte elastase and cathepsin G in the killing of Capnocytophaga sputigena

  • Infect Immun. 1992 Nov;60(11):4973-5. doi: 10.1128/iai.60.11.4973-4975.1992.
K T Miyasaki 1,  A L Bodeau
Affiliations

Affiliation

  • 1 Section of Oral Biology, UCLA School of Dentistry 90024-1668.
PMID: 1399008 DOI: 10.1128/iai.60.11.4973-4975.1992
Abstract

Azurocidin was purified in the presence of phenylmethylsulfonyl fluoride. Electrophoresis revealed at least seven species which exhibited N-terminal sequences consistent with azurocidin. Azurocidin exhibited no bactericidal activity against Capnocytophaga sputigena or other oral bacteria but synergized the bactericidal activity of enzymatically active Elastase. Azurocidin also interacted synergistically with Cathepsin G.

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