2. Academic Validation
  3. Synthesis and biological evaluation of thymine nucleosides fused with 3',4'-tetrahydrofuran ring

Synthesis and biological evaluation of thymine nucleosides fused with 3',4'-tetrahydrofuran ring

  • Bioorg Med Chem Lett. 2003 Oct 20;13(20):3499-501. doi: 10.1016/s0960-894x(03)00730-3.
Myong Jung Kim 1,  Hea Ok Kim,  Hee-Doo Kim,  Joong Hyup Kim,  Lak Shin Jeong,  Moon Woo Chun
Affiliations

Affiliation

  • 1 College of Pharmacy, Seoul National University, Seoul 151-742, South Korea.
PMID: 14505657 DOI: 10.1016/s0960-894x(03)00730-3
Abstract

The pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring were successfully synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for Antiviral activities against HIV-1, HIV-2, EMCV, COX. B3 and VSV. Thymine analogue (5) and its corresponding 2'-deoxy analogue (6) exhibited high cytotoxicity instead of giving Antiviral activities.

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