2. Academic Validation
  3. Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities

Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities

  • Bioorg Med Chem Lett. 2004 Mar 8;14(5):1193-6. doi: 10.1016/j.bmcl.2003.12.048.
Zhongze Ma 1,  Yoshio Hano,  Taro Nomura,  Yingjie Chen
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. [email protected]
PMID: 14980663 DOI: 10.1016/j.bmcl.2003.12.048
Abstract

Two new synthetic analogues of luotonins A and F, 7-acetylaminoluotonin A (6) and 3-[3H(quinazolino-4-one)]quinoline (7) were synthesized. The new analogues, along with four natural quinazoline-quinoline Alkaloids, luotonins A (1), B (2), E (3), F (4) and a synthetic deoxoluotonin F (5), showed cytotoxic activity (IC(50) 1.8-40.0 microg/mL) and DNA Topoisomerase II inhibition at a concentration of 25 microM.

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