2. Academic Validation
  3. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

  • Cancer Cell. 2004 Sep;6(3):251-61. doi: 10.1016/j.ccr.2004.07.012.
Shao-Chun Wang 1,  Huang-Chun Lien,  Weiya Xia,  I-Fen Chen,  Hui-Wen Lo,  Zhiqin Wang,  Mohamed Ali-Seyed,  Dung-Fang Lee,  Geoffrey Bartholomeusz,  Fu Ou-Yang,  Dipak K Giri,  Mien-Chie Hung
Affiliations

Affiliation

  • 1 Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
PMID: 15380516 DOI: 10.1016/j.ccr.2004.07.012
Abstract

Pathological expression of human ErbB-2 protein, also known as HER-2, is common in many types of Cancer. ErbB-2 is a member of the EGF receptor tyrosine kinase family and has been rigorously studied as a signaling molecule on the cell membrane. Here, we report that ErbB-2 is also expressed in the nucleus in cultured cells as well as primary tumor tissues. Nuclear ErbB-2 was found to associate with multiple genomic targets in vivo, including the cyclooxygenase Enzyme COX-2 gene promoter. ErbB-2 forms a complex at a specific nucleotide sequence of the COX-2 promoter and is able to stimulate its transcription. This study demonstrates the presence of ErbB-2 in the nucleus and identifies the function of ErbB-2 as a transcriptional regulator.

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