2. Academic Validation
  3. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica

Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica

  • Phytochemistry. 2004 Nov;65(22):3029-32. doi: 10.1016/j.phytochem.2004.08.050.
Abiy Yenesew 1,  Martha Induli,  Solomon Derese,  Jacob O Midiwo,  Matthias Heydenreich,  Martin G Peter,  Hoseah Akala,  Julia Wangui,  Pamela Liyala,  Norman C Waters
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Nairobi, P.O. Box 30197, Chiromo Road, Nairobi, Kenya. [email protected]
PMID: 15504437 DOI: 10.1016/j.phytochem.2004.08.050
Abstract

The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC(50) values of 7.9+/-1.1 and 5.3+/-0.7 microg/ml, respectively. From this extract, a new chalcone, 2',3,4,4'-tetrahydroxy-5-prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'-prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known Flavonoids have been isolated as the anti-plasmodial principles. The structures were determined on the basis of spectroscopic evidence.

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