2. Academic Validation
  3. Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa

Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa

  • J Med Food. 2005 Spring;8(1):107-9. doi: 10.1089/jmf.2005.8.107.
Jong Cheol Park 1,  Sang Chul Kim,  Myeong Rak Choi,  Sang Ho Song,  Eun Jeong Yoo,  Sung Hwan Kim,  Hirotsugu Miyashiro,  Masao Hattori
Affiliations

Affiliation

  • 1 Department of Oriental Medicine Resources and Research Institute of Korean Oriental Medicine, Sunchon National University, Suncheon, Jeonnam, Republic of Korea. [email protected]
PMID: 15857219 DOI: 10.1089/jmf.2005.8.107
Abstract

To identify substances with anti-human immunodeficiency virus (HIV) activity from plant sources, 12 extracts of Rosa family Plants were screened for their inhibitory effects against HIV-1 protease. Of the extracts tested, the strongest inhibitory effects were observed in the root of Rosa rugosa and the leaves of Prunus sargentii, at a concentration of 100 microg/mL. Rosamultin isolated from the root of R. rugosa inhibited HIV-1 protease by 53% at a concentration of 100 microM.

Figures
Products