2. Academic Validation
  3. Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine

Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine

  • Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):767-70. doi: 10.1081/ncn-200060112.
C Pierra 1,  S Benzaria,  A Amador,  A Moussa,  S Mathieu,  R Storer,  G Gosselin
Affiliations

Affiliation

  • 1 Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, Montpellier Cedex 5, France.
PMID: 16248033 DOI: 10.1081/ncn-200060112
Abstract

In order to improve the oral bioavailability of 2-C-methylcytidine, a potent anti-HCV agent, the corresponding 3'-O-L-valinyl ester derivative (NM 283) has been synthesized Based on its ease of synthesis and its physicochemical properties, NM 283 has emerged as a promising Antiviral drug for treatment of chronic HCV Infection.

Figures
Products