1. Anti-infection
    Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. HCV
    HCV Protease
    Nucleoside Antimetabolite/Analog
  3. Valopicitabine

Valopicitabine (Synonyms: NM283)

Cat. No.: HY-108060
Handling Instructions

Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable prodrug of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.

For research use only. We do not sell to patients.

Valopicitabine Chemical Structure

Valopicitabine Chemical Structure

CAS No. : 640281-90-9

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Description

Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable prodrug of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination[1][2].

IC50 & Target

HCV[1]

In Vivo

Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) shows the Cmax, AUC, t1/2, and tmax were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

356.37

Formula

C₁₅H₂₄N₄O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Valopicitabine
Cat. No.:
HY-108060
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