Valopicitabine
Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.
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- CAS. Nr.: 640281-90-9
- Formel: C15H24N4O6
- Molecular Weight:356.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
HCV[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>100 μM
Compound: valopicitabaine
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Cytotoxicity against Huh7 cells after 24 hrs by MTS assay
Cytotoxicity against Huh7 cells after 24 hrs by MTS assay
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[PMID: 17521911] |
| Huh-7 | CC50 |
>100 μM
Compound: 1
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Cytotoxicity against human HuH7 cells assessed as cell viability
Cytotoxicity against human HuH7 cells assessed as cell viability
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[PMID: 19493593] |
| Huh-7 | EC50 |
1.5 μM
Compound: valopicitabaine
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Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 72 hrs by ribonuclease protection assay
Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 72 hrs by ribonuclease protection assay
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[PMID: 17521911] |
| Huh-7 | EC50 |
7.45 μM
Compound: valopicitabaine
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Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 24 hrs by ribonuclease protection assay
Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 24 hrs by ribonuclease protection assay
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[PMID: 17521911] |
| Huh-7 | EC50 |
7.6 μM
Compound: 1
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Antiviral activity against HCV infected in human HuH7 cells by cell-based subgenomic replicon assay
Antiviral activity against HCV infected in human HuH7 cells by cell-based subgenomic replicon assay
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[PMID: 19493593] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 640281-90-9
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Molecular Weight 356.37
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Formel C15H24N4O6
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SMILES
C[C@@]1([C@@](N2C(N=C(C=C2)N)=O)([H])O[C@@H]([C@H]1OC([C@@H](N)C(C)C)=O)CO)O
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Synonyms
NM283
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Pierra C, et al. Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):767-70. [Content Brief]
[2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006 Nov 2;49(22):6614-20. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Valopicitabine Related Classifications
HY-108060 Related Classifications
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