Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine

  • Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):767-70. doi: 10.1081/ncn-200060112.
C Pierra  1 ,  S Benzaria ,  A Amador ,  A Moussa ,  S Mathieu ,  R Storer ,  G Gosselin
Affiliations
  • 1. Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, Montpellier Cedex 5, France.
PMID: 16248033 DOI: 10.1081/ncn-200060112
Abstract

In order to improve the oral bioavailability of 2-C-methylcytidine, a potent anti-HCV agent, the corresponding 3'-O-L-valinyl ester derivative (NM 283) has been synthesized Based on its ease of synthesis and its physicochemical properties, NM 283 has emerged as a promising Antiviral drug for treatment of chronic HCV Infection.

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