Valopicitabine dihydrochloride (Synonyms: NM283 dihydrochloride)

Name: Valopicitabine dihydrochloride
Brand: MedChemExpress
SKU: HY-108060A
Rating: 4.5 (1 reviews)

Cat. No.: HY-108060A Purity: 99.79%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.

For research use only. We do not sell to patients.

Valopicitabine dihydrochloride Chemical Structure

CAS No. : 640725-71-9

Size	Price	Stock	Quantity
5 mg	USD 430	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1300	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2050	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3200	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Valopicitabine dihydrochloride:

Valopicitabine Get quote

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) dihydrochloride shows the C_max, AUC, t_1/2, and t_max were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

429.30

Formula

C₁₅H₂₆Cl₂N₄O₆

CAS No.

640725-71-9

Appearance

Solid

Color

White to off-white

SMILES

N[C@H](C(O[C@@H]1[C@H](O[C@H]([C@]1(C)O)N2C=CC(N)=NC2=O)CO)=O)C(C)C.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (232.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (232.94 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3294 mL	11.6469 mL	23.2937 mL
5 mM	0.4659 mL	2.3294 mL	4.6587 mL
10 mM	0.2329 mL	1.1647 mL	2.3294 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.79%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (252 KB) HNMR (339 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Liu-Young G, et al. Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care STDS. 2008;22(6):449-457. [Content Brief]

[2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006;49(22):6614-6620. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.3294 mL	11.6469 mL	23.2937 mL	58.2343 mL
	5 mM	0.4659 mL	2.3294 mL	4.6587 mL	11.6469 mL
	10 mM	0.2329 mL	1.1647 mL	2.3294 mL	5.8234 mL
	15 mM	0.1553 mL	0.7765 mL	1.5529 mL	3.8823 mL
	20 mM	0.1165 mL	0.5823 mL	1.1647 mL	2.9117 mL
	25 mM	0.0932 mL	0.4659 mL	0.9317 mL	2.3294 mL
	30 mM	0.0776 mL	0.3882 mL	0.7765 mL	1.9411 mL
	40 mM	0.0582 mL	0.2912 mL	0.5823 mL	1.4559 mL
	50 mM	0.0466 mL	0.2329 mL	0.4659 mL	1.1647 mL
	60 mM	0.0388 mL	0.1941 mL	0.3882 mL	0.9706 mL
	80 mM	0.0291 mL	0.1456 mL	0.2912 mL	0.7279 mL
	100 mM	0.0233 mL	0.1165 mL	0.2329 mL	0.5823 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Valopicitabine dihydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valopicitabine640725-71-9NM283NM 283NM-283HCVHCV ProteaseNucleoside Antimetabolite/AnalogHepatitis C virusprodrugoralnucleosideanalogchainterminationpolymeraseInhibitorinhibitorinhibit

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Valopicitabine dihydrochloride (Synonyms: NM283 dihydrochloride)

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Complete Stock Solution Preparation Table

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