2. Academic Validation
  3. A new small-molecule Stat3 inhibitor

A new small-molecule Stat3 inhibitor

  • Chem Biol. 2006 Nov;13(11):1123-4. doi: 10.1016/j.chembiol.2006.11.001.
John S McMurray 1
Affiliations

Affiliation

  • 1 Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 36, Houston, Texas 77030, USA.
PMID: 17113993 DOI: 10.1016/j.chembiol.2006.11.001
Abstract

In this issue of Chemistry & Biology, Schust et al. report the discovery of a small molecule (Stattic) that inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3. Stattic is a new tool for studying STAT3 signaling and demonstrates that the SH2 domain is not a dead target.

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