2. Academic Validation
  3. Anti-sedative and anti-cataleptic properties of NCS-382, a gamma-hydroxybutyrate receptor antagonist

Anti-sedative and anti-cataleptic properties of NCS-382, a gamma-hydroxybutyrate receptor antagonist

  • Eur J Pharmacol. 1991 Oct 22;203(3):393-7. doi: 10.1016/0014-2999(91)90896-x.
C Schmidt 1,  S Gobaille,  V Hechler,  M Schmitt,  J J Bourguignon,  M Maitre
Affiliations

Affiliation

  • 1 Centre de Neurochimie, CNRS, Strasbourg, France.
PMID: 1773824 DOI: 10.1016/0014-2999(91)90896-x
Abstract

NCS-382 possesses antagonistic properties at gamma-hydroxybutyrate receptor sites. Its effect on the sedative/cataleptic behaviour observed in rats after gamma-hydroxybutyrate administration was investigated. NCS-382 diminished, in a dose-dependent manner, the sedative and/or cataleptic effects of gamma-hydroxybutyrate, as revealed by a variety of sensorimotor tests. These results indicate that the well-known sedative/anaesthetic effects induced by gamma-hydroxybutyrate administration are provoked via stimulation of a specific class(es) of gamma-hydroxybutyrate receptors which exist in the rat brain and which could mediate a local stimulation of opiate synthesis and release.

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