2. Academic Validation
  3. Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa

Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa

  • J Nat Prod. 2008 Sep;71(9):1591-4. doi: 10.1021/np800435c.
Kuan-Hon Lim 1,  Osamu Hiraku,  Kanki Komiyama,  Toh-Seok Kam
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
PMID: 18778099 DOI: 10.1021/np800435c
Abstract

Seven new Indole Alkaloids of the Aspidosperma type, jerantinines A-G (1-7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the Alkaloids isolated and two derivatives (1-5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 microg/mL).

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