2. Academic Validation
  3. Rifamycin S and its geometric isomer produced by a newly found actinomycete, Micromonospora rifamycinica

Rifamycin S and its geometric isomer produced by a newly found actinomycete, Micromonospora rifamycinica

  • Antonie Van Leeuwenhoek. 2009 Feb;95(2):143-8. doi: 10.1007/s10482-008-9297-0.
Huiqin Huang 1,  Xiaopeng Wu,  Sheng Yi,  Zhiwang Zhou,  Jun Zhu,  Zhe Fang,  Jianmin Yue,  Shixiang Bao
Affiliations

Affiliation

  • 1 Key Laboratory of Tropical Crop Biotechnology of Agriculture Ministry, Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, People's Republic of China. [email protected]
PMID: 19125348 DOI: 10.1007/s10482-008-9297-0
Abstract

Strain AM105 was separated from mangrove sediment in the South China Sea in this research. The morphological and genomic data showed that the strain merits description as a novel species, proposed as Micromonospora rifamycinica. From the acetate ethyl extract of its fermentation broth, two Antibiotics against Gram-positive bacteria (including MRSA), rifamycin S and its geometric isomer were isolated. Their structures were elucidated on the basis of spectroscopic analyzes. (1)H and (13)C NMR data of the isomer of rifamycin S were first described in this paper.

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