1. Anti-infection
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. Bacterial
    Reactive Oxygen Species
    Antibiotic
  3. Rifamycin S

Rifamycin S 

Cat. No.: HY-125365 Purity: 99.22%
Handling Instructions

Rifamycin S is a quinone and an antibiotic agnet against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy.

For research use only. We do not sell to patients.

Rifamycin S Chemical Structure

Rifamycin S Chemical Structure

CAS No. : 13553-79-2

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10 mM * 1  mL in DMSO USD 99 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Rifamycin S is a quinone and an antibiotic agnet against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy[1][2][3].

IC50 & Target

Gram-positive bacteria[3]
Reactive oxygen species (ROS)[1]

In Vitro

The inhibition of bacterial growth by Rifamycin SV is due to the production of active species of oxygen resulting from the oxidation-reduction cycle of Rifamycin SV in the cells. The aerobic oxidation of Rifamycin SV to Rifamycin S is induced by metal ions, such as Mn2+, Cu2+, and Co2+. The most effective metal ion is Mn2+[2].

In Vivo

Rat liver sub-mitochondrial particles also generated hydroxyl radical in the presence of NADH and Rifamycin S. NADH dehydrogenase (complex I) as the major component involved in the reduction of Rifamycin S. Compared to NADPH, NADH is almost as effective (Rifamycin S) in catalyzing the interactions of these antibiotics with rat liver microsomes. Rifamycin S is shown to be readily reduced to Rifamycin SV, the corresponding hydroquinone by Fe(II). Rifamycin S forms a detectable Fe(II)-(Rifamycin S)3 complex. The Fe:ATP induced lipid peroxidation is completely inhibited by Rifamycin S. Rifamycin S can interact with rat liver microsomes to undergo redox-cycling, with the subsequent production of hydroxyl radicals when iron complexes are present[1].

Clinical Trial
Molecular Weight

695.75

Formula

C₃₇H₄₅NO₁₂

CAS No.

13553-79-2

SMILES

O=C1C2=C(C(C=C3NC(/C(C)=C/C=C/[[email protected]](C)[[email protected]](O)[[email protected]@H](C)[[email protected]@H](O)[[email protected]]4C)=O)=O)C(C3=O)=C(O)C(C)=C2O[[email protected]@]1(O/C=C/[[email protected]@H]([[email protected]]([[email protected]@]4([H])OC(C)=O)C)OC)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (359.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4373 mL 7.1865 mL 14.3730 mL
5 mM 0.2875 mL 1.4373 mL 2.8746 mL
10 mM 0.1437 mL 0.7186 mL 1.4373 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Rifamycin SBacterialReactive Oxygen SpeciesAntibioticRifamycintuberculosisleprosyNADPHoxidizedNADHantibioticssub-mitochondrialROSInhibitorinhibitorinhibit

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Rifamycin S
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