2. Academic Validation
  3. Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea

Cassiarins C-E, antiplasmodial alkaloids from the flowers of Cassia siamea

  • J Nat Prod. 2009 Oct;72(10):1899-901. doi: 10.1021/np9004213.
Shiori Oshimi 1,  Jun Deguchi,  Yusuke Hirasawa,  Wiwied Ekasari,  Aty Widyawaruyanti,  Tutik Sri Wahyuni,  Noor Cholies Zaini,  Osamu Shirota,  Hiroshi Morita
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
PMID: 19754128 DOI: 10.1021/np9004213
Abstract

Three new Alkaloids, cassiarins C-E (1-3), and a new chromone, 10,11-dihydroanhydrobarakol (4), which showed moderate antiplasmodial activity against Plasmodium falciparum 3D7, were isolated from flowers of Cassia siamea, and the structures of 1-4 were elucidated by 2D NMR analysis and chemical transformation. Cassiarin D (2) was a dimeric compound consisting of 5-acetonyl-7-hydroxy-2-methylchromone and cassiarin C (1), and cassiarin E (3) was a dimer of cassiarins A and C (1).

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