2. Academic Validation
  3. COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans

COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans

  • Bioorg Med Chem Lett. 2009 Dec 15;19(24):6922-5. doi: 10.1016/j.bmcl.2009.10.069.
Ericsson David Coy 1,  Luis Enrique Cuca,  Michael Sefkow
Affiliations

Affiliation

  • 1 Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Química, Laboratorio de Investigación en Productos Naturales Vegetales, AA 14490, Bogotá DC, Colombia. [email protected]
PMID: 19880317 DOI: 10.1016/j.bmcl.2009.10.069
Abstract

The anti-inflammatory potential of 26 neolignans (14 of the bicyclooctane-type and 12 of the benzofuran-type), isolated from three Lauraceae species (Pleurothyrium cinereum, Ocotea macrophylla and Nectandra amazonum), was evaluated in vitro through inhibition of COX-1, COX-2, 5-LOX and agonist-induced aggregation of rabbit platelets. Benzofuran neolignans were found to be selective COX-2 inhibitors, whereas bicyclooctane neolignans inhibit selectively the PAF-action as well as COX-1 and 5-LOX. The neolignan 9-nor-7,8-dehydro-isolicarin B 15 and cinerin C 7 were found to be the most potent COX-2 Inhibitor and PAF-antagonist, respectively. Nectamazin C 10 exhibited dual 5-LOX/COX-2 inhibition.

Figures