2. Academic Validation
  3. Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate

Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate

  • Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1300-2. doi: 10.1248/cpb.57.1300.
Vanessa Gonnot 1,  Marc Nicolas,  Charles Mioskowski,  Rachid Baati
Affiliations

Affiliation

  • 1 Faculty of Pharmacy, University of Strasbourg, CNRS-UMR 7199, 74 route du Rhin, 67401 Illkirch, France.
PMID: 19881287 DOI: 10.1248/cpb.57.1300
Abstract

A short and straightforward synthesis of the antihistaminic drug mequitazine is reported, based on an efficient palladium catalyzed allylic alkylation of 1-aza-bicyclo[2.2.2]oct-2-en-3-ylmethyl acetate using sodium phenothiazinate in mild conditions.

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