1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

Mequitazine 

Cat. No.: HY-B2168 Purity: 99.47%
Handling Instructions

Mequitazine is a potent, nonsedative and long-acting histamine H1 antagonist.

For research use only. We do not sell to patients.

Mequitazine Chemical Structure

Mequitazine Chemical Structure

CAS No. : 29216-28-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
25 mg USD 144 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
100 mg USD 228 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Mequitazine is a potent, nonsedative and long-acting histamine H1 antagonist.

In Vitro

Mequitazine is a potent H1-receptors selective antihistaminic drug widely studied and used for allergic disorders such as hay fever and urticaria[1]. Mequitazine demonstrates significant bactericidal effects against all the tested clinical isolates including Ps. aeruginosa. Its effect against the Gram-positive isolates is more pronounced[2].

In Vivo

Mequitazine and clemizole antagonize the effect of histamine in guinea-pig ileum competitively. Mequitazine at 107 produces a parallel shift of the dose-response curve to acetylcholine in the rat duodenum. Mequitazine at highest concentration shows anticholinergic activity[3]. Mequitazine inhibits contractile responses to KCl, phenylephrine (PE), 5-hydroxytryptamine (5-HT), and Ca2+ in rat aorta[4].

Solvent & Solubility
In Vitro: 

DMSO : 16 mg/mL (49.62 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1011 mL 15.5053 mL 31.0106 mL
5 mM 0.6202 mL 3.1011 mL 6.2021 mL
10 mM 0.3101 mL 1.5505 mL 3.1011 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

322.47

Formula

C₂₀H₂₂N₂S

CAS No.

29216-28-2

SMILES

C12=CC=CC=C1N(CC3CN4CCC3CC4)C5=C(C=CC=C5)S2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Mequitazine
Cat. No.:
HY-B2168
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Mequitazine

Cat. No.: HY-B2168