2. Academic Validation
  3. Vitamin K(3) and K(5) are inhibitors of tumor pyruvate kinase M2

Vitamin K(3) and K(5) are inhibitors of tumor pyruvate kinase M2

  • Cancer Lett. 2012 Mar 28;316(2):204-10. doi: 10.1016/j.canlet.2011.10.039.
Jing Chen 1,  Zheng Jiang,  Beibei Wang,  Yanguang Wang,  Xun Hu
Affiliations

Affiliation

  • 1 Cancer Institute a Key Laboratory for Cancer Prevention & Intervention, National Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
PMID: 22154083 DOI: 10.1016/j.canlet.2011.10.039
Abstract

Pyruvate Kinase M2 (PKM2) is a rate-limiting Enzyme of aerobic glycolysis in Cancer cells and plays important roles in Cancer metabolism and growth. Here we show that vitamin K(3) and K(5) (VK(3) and VK(5)) are relatively specific PKM2 inhibitors. VK(3) and VK(5) showed a significantly stronger potency to inhibit PKM2 than to inhibit PKM1 and PKL, 2 other isoforms of PK dominantly expressed in most adult tissues and liver. This study combined with previous reports supports that VK(3) and VK(5) have potential as adjuvant for Cancer chemotherapy.

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