2. Academic Validation
  3. Protein engineering of penicillin acylase

Protein engineering of penicillin acylase

  • Acta Naturae. 2010 Jul;2(3):47-61.
V I Tishkov 1,  S S Savin,  A S Yasnaya
Affiliations

Affiliation

  • 1 Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University.
PMID: 22649651
Abstract

Penicillin acylases (PA) are widely used for the production of semi-synthetic β-lactam Antibiotics and chiral compounds. In this review, the latest achievements in the production of recombinant enzymes are discussed, as well as the results of PA type G protein engineering.

Keywords

E.coli; expression; penicillin acylase; protein engineering; structure.

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