2. Academic Validation
  3. Sortase A inhibitory metabolites from the roots of Pulsatilla koreana

Sortase A inhibitory metabolites from the roots of Pulsatilla koreana

  • Bioorg Med Chem Lett. 2014 Jan 1;24(1):44-8. doi: 10.1016/j.bmcl.2013.12.006.
Sooryun Lee 1,  Inn-Hye Song 1,  Jung-Ho Lee 1,  Woo-Young Yang 2,  Ki-Bong Oh 3,  Jongheon Shin 4
Affiliations

Affiliations

  • 1 Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Republic of Korea.
  • 2 Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Republic of Korea.
  • 3 Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Republic of Korea. Electronic address: [email protected].
  • 4 Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Republic of Korea. Electronic address: [email protected].
PMID: 24360605 DOI: 10.1016/j.bmcl.2013.12.006
Abstract

Three new Lignans (3, 4, and 6) along with eight known Lignans and phenyl propanoids were isolated from the dried roots of Pulsatilla koreana, an oriental folk medicine. Based upon the results of combined spectroscopic and chemical methods, the structures of new compounds were determined to be lignan glycosides. Included among the known compounds are three compounds (5, 7, and 8) isolated first time from this plant as well as two compounds (2 and 11) previously reported only as synthetic derivatives. These compounds significantly inhibited the action of Sortase A from Streptococcus mutans OMZ65, an isolate from human oral cavity.

Keywords

Lignans; Phenyl propanoid; Pulsatilla koreana; Sortase A.

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