(7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside
(7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside is a Streptococcus mutans Sortase A inhibitor with an IC50 of 37.3 μM. (7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside inhibits transpeptidase activity linked to Gram-positive bacterial surface protein anchoring. (7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside can be used for the research of dental caries.
For research use only. We do not sell to patients.
- CAS No.: 1526987-82-5
- Formula: C26H34O11
- Molecular Weight:522.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
(7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside (concentrations to determine IC50; 1 h at 37 °C) potently inhibits recombinant Streptococcus mutans OMZ65 SrtA with an IC50 of 37.3 μM, and glycosylation at its C-9' position does not alter this inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1526987-82-5
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Molecular Weight 522.54
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Formula C26H34O11
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SMILES
OC[C@@H]1C2=CC(CCCO[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=CC(OC)=C2O[C@@H]1C4=CC(OC)=C(C=C4)O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside Related Classifications
HY-N17582 Related Classifications
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