1. Academic Validation
  2. Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial

Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial

  • J Investig Clin Dent. 2015 Aug;6(3):170-8. doi: 10.1111/jicd.12091.
Avani R Pradeep 1 Sonender P Singh 1 Santosh S Martande 1 Savitha B Naik 2 Priyanka N 2 Nitish Kalra 1 Deepak K Suke 1
Affiliations

Affiliations

  • 1 Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
  • 2 Department of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
Abstract

Aim: The aim of the present study was to evaluate the clinical and microbiological effect of systemic levofloxacin (LFX) as an adjunct to scaling and root planing (SRP) in patients with chronic periodontitis (CP).

Methods: Sixty-five patients with CP were randomly divided into a test (n = 33, SRP and LFX 500 mg, once daily [o.d.]) and a control group (n = 32, SRP and placebo, o.d.). Plaque index (PI), gingival index (GI), percentage of sites with bleeding on probing (%BoP), probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 10 days, and 1-, 3-, and 6-month intervals. The percentage of sites positive for Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis, and Tannerella forsythia were recorded at baseline and at 3 and 6 months.

Results: Patients receiving LFX showed statistically-significant improvements in mean PD and CAL. The intergroup difference in PI, GI, and%BoP was not significant at any interval. There was a reduction in the percentage of sites positive for periodontopathic bacteria over the duration of the study in both groups, and a statistically-significant reduction in the number of sites positive for A. actinomycetemcomitans in the LFX group (P < 0.001).

Conclusion: Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP individuals.

Keywords

antimicrobial; chronic periodontitis; clinical and microbiological effect; levofloxacin; scaling and root planing.

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