1. Academic Validation
  2. MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells

MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells

  • Apoptosis. 2015 Jan;20(1):75-82. doi: 10.1007/s10495-014-1047-3.
Wei-Ming Fu 1 Li-Peng Tang Xiao Zhu Ying-Fei Lu Yan-Ling Zhang Wayne Yuk-Wai Lee Hua Wang Yang Yu Wei-Cheng Liang Chun-Hay Ko Hong-Xi Xu Hsiang-Fu Kung Jin-Fang Zhang
Affiliations

Affiliation

  • 1 School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Abstract

Traditional Chinese medicine is recently emerged as anti-cancer therapy or adjuvant with reduced side-effects and improved quality of life. In the present study, an active ingredient, 1,6,7-trihydroxyxanthone (THA), derived from Goodyera oblongifolia was found to strongly suppress cell growth and induce Apoptosis in liver Cancer cells. MicroRNAs are a group of small non-coding RNAs that regulate gene expression at post-transcriptional levels. Our results demonstrated that miR-218 was up-regulated and oncogene Bmi-1 was down-regulated by THA treatment. Further investigation showed that THA-induced-miR-218 up-regulation could lead to activation of tumor suppressor P16(Ink4a) and P14(ARF), the main down-stream targets of Bmi-1. In conclusion, THA might be a potential anti-cancer drug candidate, at least in part, through the activation of miR-218 and suppression of Bmi-1 expression.

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